2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase

NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N9675
    (+)-Hannokinol
    		Inhibitor
    (+)-Hannokinol can be isolated from AMOMUM TSAO-KO (ginger family) fruit. (+)-Hannokinol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia.
    (+)-Hannokinol
  • HY-N15221
    12-Acetoxyganoderic acid D
    		Inhibitor
    12-Acetoxyganoderic acid D is a triterpenoid compound found in Ganoderma sinense. 12-Acetoxyganoderic acid D exhibits certain anti-inflammatory activity and inhibits NO production in LPS (HY-D1056) stimulated RAW 264.7 macrophages.
    12-Acetoxyganoderic acid D
  • HY-N15226
    Butyrolactone Ia
    		Inhibitor
    Butyrolactone Ia is the inhibitor for the NO production with an IC50 of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity.
    Butyrolactone Ia
  • HY-170957
    5-LOX/NO-IN-1
    		Inhibitor
    5-LOX/NO-IN-1 (Compound 7e) is a 5-LOX and NO release inhibitor. 5-LOX/NO-IN-1 shows an IC50 of 2.833 μM for 5-LOX. 5-LOX/NO-IN-1 has anti-inflammatory effects.
    5-LOX/NO-IN-1
  • HY-147769
    Anti-inflammatory agent 23
    		Inhibitor
    Anti-inflammatory agent 23 (Compound 4m) is an anti-inflammatory agent. Anti-inflammatory agent 23 inhibits the production of NO activated by LPS with an IC50 of 0.449 μM. Anti-inflammatory agent 23 has a good affinity for p65 protein.
    Anti-inflammatory agent 23
  • HY-N9376
    Kansuinine E
    		Inhibitor
    Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui.
    Kansuinine E
  • HY-B1409S
    Isosorbide dinitrate-13C6
    Isosorbide dinitrate-13C6 is the 13C labeled Isosorbide dinitrate. Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI).
    Isosorbide dinitrate-<sup>13</sup>C<sub>6</sub>
  • HY-117601
    11-Deoxyalisol B
    		Inhibitor
    11-Deoxyalisol B, a triterpene, shows the potent inhibitory activity on Lipopolysaccharide (LPS)-induced nitric oxide (NO) production.
    11-Deoxyalisol B
  • HY-N8477
    Isolupalbigenin
    		Inhibitor
    Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC50 of 5.1 μM.
    Isolupalbigenin
  • HY-N8631
    O-Acetylschisantherin L
    		Inhibitor
    O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC50 of 23.1 μM.
    O-Acetylschisantherin L
  • HY-115917
    NOS-IN-3
    		Inhibitor
    NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 μM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the research of inducible isoform involved diseases, such as septic shock.
    NOS-IN-3
  • HY-143457
    Anti-inflammatory agent 19
    		Inhibitor
    Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
    Anti-inflammatory agent 19
  • HY-N8174
    Valeriandoid F
    		Inhibitor
    Valeriandoid F is an iridoid, which potently inhibits NO production with an IC50 value of 0.88 μM. Valeriandoid F has anti-inflammatory and antiproliferative activities.
    Valeriandoid F
  • HY-145908
    Antitumor agent-49
    		Activator
    Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC50 of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro.
    Antitumor agent-49
  • HY-N0918R
    Desmethoxyyangonin (Standard)
    		Inhibitor
    Desmethoxyyangonin (Standard) is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin (Standard) is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC50: 0.123  µM). Desmethoxyyangonin (Standard) exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin (Standard) induces CYP3A23 expression and leads to skeletal muscle relaxation.
    Desmethoxyyangonin (Standard)
  • HY-N3426
    Kazinol B
    		Inhibitor
    Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research.
    Kazinol B
  • HY-18252S3
    Avanafil-13C5
    		Inhibitor
    Avanafil-13C5 (TA1790-13C5) is 13C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis.
    Avanafil-<sup>13</sup>C<sub>5</sub>
  • HY-164361
    2′-Hydroxy-2,3-dimethoxychalcone
    		Inhibitor
    α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells.
    2′-Hydroxy-2,3-dimethoxychalcone
  • HY-165255
    N-Isobutyl decanamide
    		Inducer
    N-Isobutyl decanamide is a plant growth regulator. N-Isobutyl decanamide promotes the development of adventitious roots in hypocotyl explants of A. thaliana and lateral roots in taproot explants. N-Isobutyl decanamide induces the accumulation of NO in the proliferative sites of adventitious roots.
    N-Isobutyl decanamide
  • HY-169974
    SARS-CoV-2-IN-107
    		Inhibitor
    SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages.
    SARS-CoV-2-IN-107
Cat. No. Product Name / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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