2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase

NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-133198
    Valeriandoid B
    		Inhibitor
    Valeriandoid B is a Iridoids product that can be isolated from the herbs of Valeriana jatamansi.
    Valeriandoid B
  • HY-N0577R
    Apiin (Standard)
    		Inhibitor
    Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells.
    Apiin (Standard)
  • HY-N12317
    Multiflorin B
    Multiflorin B (compound 5) is a kind of kaempferol glycoside. Multiflorin B can be isolated from the root of the fern Neocheiropteris palmatopedata. Multiflorin B inhibits nitric oxide production at a concentration of 20 μg/ml with an inhibition of 52%.
    Multiflorin B
  • HY-155224
    Sulpho NONOate
    		Control
    Sulpho NONOate (Sulfi/NO) does not produce NO at physiological pH. Sulpho NONOate can be used in the experiments about other NO-donor regents as a negative control.
    Sulpho NONOate
  • HY-N0455AS9
    L-Arginine-15N4,d7 hydrochloride
    		Activator
    L-Arginine-15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
    L-Arginine-<sup>15</sup>N<sub>4</sub>,d<sub>7</sub> hydrochloride
  • HY-W003969R
    Aminopicoline (Standard)
    		Inhibitor
    Aminopicoline (Standard) is the analytical standard of Aminopicoline. This product is intended for research and analytical applications. Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS).
    Aminopicoline (Standard)
  • HY-18732C
    L-NMMA hydrochloride
    		Antagonist
    L-NMMA (Tilarginine) hydrochloride competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA hydrochloride is utilized as NO synthase antagonist in experimental settings.
    L-NMMA hydrochloride
  • HY-W408607
    N-Benzylacetamidine hydrobromide
    		Inhibitor
    N-Benzylacetamidine (hydrobromide) is a acetamidine compound. N-Benzylacetamidine (hydrobromide) is a selective inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 0.20 μM.
    N-Benzylacetamidine hydrobromide
  • HY-N15347
    Talaromyketide B
    		Inhibitor
    Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases.
    Talaromyketide B
  • HY-N2715A
    (2R)-6-Methoxynaringenin
    		Inhibitor
    (2R)-6-Methoxynaringenin is the R isomer of 6-Methoxynaringenin (HY-N2715). 6-Methoxynaringenin is a flavonoid, that inhibits NO production with an IC50 of 25.8 μM.
    (2R)-6-Methoxynaringenin
  • HY-108054
    Cindunistat
    		Inhibitor
    Cindunistat (SD-6010) is a potent, orally active and selective iNOS inhibitor.
    Cindunistat
  • HY-18252S2
    Avanafil-d4
    		Inhibitor
    Avanafil-d4 (TA1790-d4) is deuterium-labeled Avanafil (HY-18252).
    Avanafil-d<sub>4</sub>
  • HY-121174
    Alaternin
    		Inhibitor
    Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM.
    Alaternin
  • HY-N1695
    Demethylregelin
    		Inhibitor
    Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of iNOS protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities.
    Demethylregelin
  • HY-115410
    NG-Amino-L-arginine hydrochloride
    		Inhibitor
    NG-Amino-L-arginine hydrochloride induces inactivation of the citrulline-forming activity of the nNOS, iNOS, and eNOS isoforms with Ki values of 0.3 μM, 3 μM, and 2.5 μM, respectively.
    NG-Amino-L-arginine hydrochloride
  • HY-N3211
    N-cis-Feruloyl tyramine
    		Inhibitor
    N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells.
    N-cis-Feruloyl tyramine
  • HY-18732
    L-NMMA
    		Antagonist
    L-NMMA (Tilarginine; Methylarginine) competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA is utilized as NO synthase antagonist in experimental settings.
    L-NMMA
  • HY-U00187
    NCX1022
    		Activator
    NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory agent for the treatment of skin inflammation.
    NCX1022
  • HY-P0316
    TP508
    		Activator
    TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.
    TP508
  • HY-U00273
    Anti-inflammatory agent 1
    		Inhibitor
    Anti-inflammatory agent 1 is an anti-inflammatory agent extracted from patent WO 2009003229 A1, example 36.
    Anti-inflammatory agent 1
Cat. No. Product Name / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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